Natural selection against a circadian clock gene mutation in mice.

  title={Natural selection against a circadian clock gene mutation in mice.},
  author={Kamiel Spoelstra and Martin Wikelski and Serge Daan and Andrew S. I. Loudon and Michaela Hau},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 3},
Circadian rhythms with an endogenous period close to or equal to the natural light-dark cycle are considered evolutionarily adaptive ("circadian resonance hypothesis"). Despite remarkable insight into the molecular mechanisms driving circadian cycles, this hypothesis has not been tested under natural conditions for any eukaryotic organism. We tested this hypothesis in mice bearing a short-period mutation in the enzyme casein kinase 1ε (tau mutation), which accelerates free-running circadian… CONTINUE READING
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