Natural selection: Evolution of lifespan in C. elegans

@article{Walker2000NaturalSE,
  title={Natural selection: Evolution of lifespan in C. elegans},
  author={David W. Walker and Gawain McColl and Nicole L. Jenkins and Jennifer M. Harris and Gordon J. Lithgow},
  journal={Nature},
  year={2000},
  volume={405},
  pages={296-297}
}
It was proposed almost 50 years ago that ageing is non-adaptive and is the consequence of a decline in the force of natural selection with age. This led to the theory that ageing results from detrimental effects late in life of genes that act beneficially in early life, so any genetic alteration that increases lifespan might be expected to reduce fitness, for example. We show here that a mutation that greatly increases the lifespan of the nematode Caenorhabditis elegans does indeed exhibit a… 

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