Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry.

@article{Benner1987NaturalSP,
  title={Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry.},
  author={S. A. Benner and Rudolf K Allemann and Andrew D. Ellington and Lynn Ge and A Glasfeld and G F Leanz and Tilman Krauch and Louis Macpherson and Sue Moroney and Joseph A Piccirilli},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={1987},
  volume={52},
  pages={53-63}
}
A detailed study of the chemical behavior of modern catalysts (here, exemplified by dehydrogenases dependent on NAD+) allows us to construct models that distinguish between selected and drifting behaviors in biological macromolecules. These models enable us to manipulate rationally the properties of enzymes, here to design an "acetaldehyde reductase" dependent on NAD+ that is faster than any given us by nature. When applied to the origin of protein catalysis, models that explain the structures… CONTINUE READING

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