Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies

  title={Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies},
  author={Frederico Martinon-Torres and Eileen Png and Chiea Chuen Khor and Sonia D{\'a}vila and Victoria J. Wright and Kar Seng Sim and Ana Isabel Vega and Laura Fachal and David Inwald and Simon Nadel and Enitan D. Carrol and Nazareth Martin{\'o}n-Torres and Sonia Marcos Alonso and {\'A}ngel Carracedo and Elvira Morteruel and Julio L{\'o}pez-Bay{\'o}n and Andr{\'e}s Concha Torre and Cristina Calvo Monge and Pilar Azc{\'o}n Gonz{\'a}lez de Aguilar and Elisabeth Esteban Torn{\'e} and Mar{\'i}a del Carmen Mart{\'i}nez-Padilla and Jos{\'e} Mar{\'i}a Martin{\'o}n-S{\'a}nchez and Michael Levin and Martin L. Hibberd and Antonio Salas and Alberto G{\'o}mez-Carballa and Miriam Cebey and Natalia Garc{\'i}a S{\'a}nchez and Irene Rivero Calle and Antonio Justicia Grande and Jacobo Pardo-Seco and Ruth Barral-Arca and Sara Pischedda and Mar{\'i}a-Jos{\'e} Curr{\'a}s-Tuala and Carmen Rodriguez-Tenreiro and Lorenzo Redondo-Collazo and Fernanda Pardo S{\'a}nchez and Jes{\'u}s de la Cruz Moreno and Mª. Leticia Mill{\'a}n Miralles and Jos{\'e} Luis Garc{\'i}a Rodr{\'i}guez and Susana Rey Garc{\'i}a and Ana Hurtado Doce and {\'A}ngela Ferrer Barba and Manuel Ortiz Pallares and Alfredo Reparaz Romero and Juan Ignacio Mu{\~n}oz Bonet and Manuel Silveira Cancela and Eider O{\~n}ate Bergara and Amaya Bustinza Arriortua and Mar{\'i}a Luisa Navarro G{\'o}mez and Mario Jos{\'e} S{\'a}nchez Fern{\'a}ndez and Xavier Allu{\'e} Mart{\'i}nez and {\'A}lvaro Castellanos Ortega and Servando Pantoja Rosso and C{\'e}sar P{\'e}rez Caballero Macarr{\'o}n and Natalia Molini Mench{\'o}n and Francisco Gim{\'e}nez S{\'a}nchez and Manuel Gonz{\'a}lez-Ripoll Garz{\'o}n and Mar{\'i}a del Mar Ballesteros Garc{\'i}a and Jos{\'e} Manuel S{\'a}nchez Granados and Olga Serrano Ayestar{\'a}n and Roman Payo and Sonia Ca{\~n}adas Palaz{\'o}n and Maria Cruz Le{\'o}n Le{\'o}n and Susana Reyes Dominguez and David Arjona Villanueba and J. Antonio Alonso Mart{\'i}n and Concepci{\'o}n Go{\~n}i Orayen and Enrique Bernaola Iturbe and Mar{\'i}a Teresa Alonso Salas and Isabel Quintela Fern{\'a}ndez and Robert Booy and Lachlan J M Coin and Hariklia Eleftherohorinou and Saul Faust and Rachel Galassini and Parviz Habibi and Elene Haralambous and Simon Kroll and Paul R Langford and Nazima Pathan and Andrew J Pollard and Farhana Abdulla and Paul Agapow and Evangelos Bellos and Shea Hamilton and Jethro A Herberg and Clive L Hoggart and Myrsini Kaforou and Meg Mashbat and S Shahzad Mustafa and Vanessa Sancho-Shimizu},
  booktitle={Scientific reports},
Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts… CONTINUE READING