Natural resistance to HIV infection: The Vif-APOBEC interaction

@inproceedings{Malim2006NaturalRT,
  title={Natural resistance to HIV infection: The Vif-APOBEC interaction},
  author={Michael H Malim},
  year={2006}
}
Abstract Members of the APOBEC family of cellular polynucleotide cytidine deaminases (e.g., APOBEC3G) are potent inhibitors of HIV infection. Wild type viral infections are largely spared from APOBEC function through the action of the viral Vif protein. In Vif's absence, inhibitory APOBEC proteins are encapsidated by budding virus particles leading to excessive cytidine (C) to uridine (U) hypermutation of negative sense reverse transcripts in newly infected cells. This registers as guanosine (G… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS