Natural regulatory T cells are resistant to calcium release-activated calcium (CRAC/ORAI) channel inhibition.

@article{Jin2013NaturalRT,
  title={Natural regulatory T cells are resistant to calcium release-activated calcium (CRAC/ORAI) channel inhibition.},
  author={Shu Jin and Jayne Chin and Christopher Kitson and John Woods and Rupal Majmudar and Valerie Carvajal and John R. Allard and Julie Demartino and Satwant K. Narula and Dori A Thomas-Karyat},
  journal={International immunology},
  year={2013},
  volume={25 9},
  pages={497-506}
}
Organ transplant patients are often treated with immunosuppressants, such as the calcineurin phosphatase inhibitor, cyclosporin A, to block T cell-mediated graft rejection. The calcium release-activated calcium (CRAC/ORAI) channels, which act upstream of calcineurin, are essential for calcium entry and CD4(+) T-cell activation. Although cyclosporine A has also been shown to inhibit FoxP3(+) Tregs both in vitro and in vivo, the role of ORAI channel inhibition in natural Tregs (nTregs) or… CONTINUE READING

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