Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis.

@article{Yates2008NaturalRT,
  title={Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis.},
  author={John Russel Yates and Alison Whittington and Peter Mitchell and R. Lechler and Liz B Lightstone and Giovanna Lombardi},
  journal={Clinical and experimental immunology},
  year={2008},
  volume={153 1},
  pages={
          44-55
        }
}
CD4(+) CD25(+) regulatory T cells have been shown to be a vital component of the mechanisms that prevent autoreactivity in mice and also in humans. Previous studies have examined CD4(+) CD25(hi) regulatory T cell frequency and function in patients with systemic lupus erythematosus (SLE) with mixed results. We investigated frequency, phenotype and function in 21 patients with SLE and six with inactive disease. We found no reduction in frequency of the CD25(hi) subset, although active disease was… CONTINUE READING
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