Natural regulation of immunity to minor histocompatibility antigens.

@article{Robertson2007NaturalRO,
  title={Natural regulation of immunity to minor histocompatibility antigens.},
  author={Nathan J. Robertson and Jian-Guo Chai and Maggie Millrain and Diane Scott and Fazila Hashim and Emily J. Manktelow and François A. Lemonnier and Elizabeth Simpson and Julian P. Dyson},
  journal={Journal of immunology},
  year={2007},
  volume={178 6},
  pages={
          3558-65
        }
}
MHC-matched hemopoietic stem cell transplantation is commonly used for the treatment of some forms of leukemia. Conditioning regimens before transplant act to reduce the burden of leukemic cells and the graft-vs-leukemia (GvL) effect can eliminate residual disease. The GvL effect results largely from the recognition of minor histocompatibility Ags by donor T cells on recipient tissues. These Ags are generally widely expressed and also provoke graft-vs-host (GvH) disease. Manipulation of… CONTINUE READING

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