Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.
@article{Zhang2002NaturalPI, title={Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.}, author={Zhizhen Zhang and Hala N. Elsohly and Melissa R. Jacob and David S. Pasco and Larry A. Walker and Alice Mae Clark}, journal={Journal of natural products}, year={2002}, volume={65 7}, pages={ 979-85 } }
Activity-guided fractionation of an ethanol extract of Lycopodium cernuum for Candida albicans secreted aspartic proteases (SAP) inhibition resulted in the identification of six new (1-6) and four known (7-10) serratene triterpenes, along with the known apigenin-4'-O-(2' ',6' '-di-O-p-coumaroyl)-beta-D-glucopyranoside (11). On the basis of spectroscopic analysis, the structures of 1-10 were established as 3beta,14alpha,15alpha,21beta,29-pentahydroxyserratane-24-oic acid (lycernuic acid C, 1…
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