Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.

  title={Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.},
  author={Zhizhen Zhang and Hala N. Elsohly and Melissa R. Jacob and David S. Pasco and Larry A. Walker and Alice Mae Clark},
  journal={Journal of natural products},
  volume={65 7},
Activity-guided fractionation of an ethanol extract of Lycopodium cernuum for Candida albicans secreted aspartic proteases (SAP) inhibition resulted in the identification of six new (1-6) and four known (7-10) serratene triterpenes, along with the known apigenin-4'-O-(2' ',6' '-di-O-p-coumaroyl)-beta-D-glucopyranoside (11). On the basis of spectroscopic analysis, the structures of 1-10 were established as 3beta,14alpha,15alpha,21beta,29-pentahydroxyserratane-24-oic acid (lycernuic acid C, 1… 
Triterpenoid from Lycopodium obscurum L.
To study the triterpenoid constituents from air-dried whole plants of Lycopodium obscurum L., the constituents were isolated by normal-phase and reverse-phase silica gel column chromatography from
New serratene triterpenoids from Palhinhaea cernua and their cytotoxic activity.
Four new serratene triterpenoids, 3β,21β,24-trihydroxyserrat-14-en-24-(4'-hydroxybenzoate) and two known compounds, 5 and 6, together with two known ones, were isolated from whole plants of Palhinhaea cernua.
Serratene triterpenoids from Palhinhaea cernua var. sikkimensis.
Seven new serratene triterpenoids were isolated from Palhinhaea cernua var.
Polyhydroxyserratane triterpenoids from Diphasiastrum complanatum.
Chemical constituents from Lycopodiella cernua and their anti-inflammatory and cytotoxic activities.
Phytochemical investigation of the whole plants of Lycopodiella cernua resulted in the isolation and identification of three new compounds, namely lycocernuaside E, ly Concernuic ketone F, and lycernuic B, and 12 known ones and cytotoxic activity of the isolated compounds against MCF7, HepG2, and SK-Mel2 cancer cell lines were reported.
Isolation of cholinesterase and β-secretase 1 inhibiting compounds from Lycopodiella cernua.
7-hydroxycalamenene Effects on Secreted Aspartic Proteases Activity and Biofilm Formation of Candida spp.
Background: The 7-hydroxycalamenenene-rich essential oil (EO) obtained from the leaves of Croton cajucara (red morphotype) have been described as active against bacteria, protozoa, and fungi species.
A new serratene triterpenoid from Lycopodium japonicum
Abstract Phytochemical investigation on the herbs of Lycopodium japonicum led to the isolation of a new serratene triterpenoid, 3α,21α-dihydroxy-16-oxoserrat-14-en-24-yl p-coumarate (1), together