Natural products as targeted modulators of the nuclear factor‐KB pathway

  title={Natural products as targeted modulators of the nuclear factor‐KB pathway},
  author={Paul D. Bremner and Michael Heinrich},
  journal={Journal of Pharmacy and Pharmacology},
The use of plant extracts to alleviate inflammatory diseases is centuries old and continues to this day. This review assesses the current understanding of the use of such plants and natural products isolated from them in terms of their action against the ubiquitous transcription factor, nuclear factor kappa B (NF‐κB). As an activator of many pro‐inflammatory cytokines and inflammatory processes the modulation of the NF‐κB transduction pathway is a principal target to alleviate the symptoms of… 

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