Natural products as targeted modulators of the nuclear factor‐KB pathway

@article{Bremner2002NaturalPA,
  title={Natural products as targeted modulators of the nuclear factor‐KB pathway},
  author={Paul D. Bremner and Michael Heinrich},
  journal={Journal of Pharmacy and Pharmacology},
  year={2002},
  volume={54}
}
The use of plant extracts to alleviate inflammatory diseases is centuries old and continues to this day. This review assesses the current understanding of the use of such plants and natural products isolated from them in terms of their action against the ubiquitous transcription factor, nuclear factor kappa B (NF‐κB). As an activator of many pro‐inflammatory cytokines and inflammatory processes the modulation of the NF‐κB transduction pathway is a principal target to alleviate the symptoms of… 
View on Wiley
ncbi.nlm.nih.gov
310 Citations
Highly Influential Citations
6
Background Citations
114
Methods Citations
8
Results Citations
6

310 Citations

Marine natural products as targeted modulators of the transcription factor NF-κB

Natural Products and their Role as Inhibitors of the Pro-Inflammatory Transcription Factor NF-κB

This review briefly expands on information on biogenic modulator of this transcription factor published since an earlier review in 2002 and goes into much more detail on parthenolide and curcumin – two natural products that have been at the centre of molecular and biochemical interest in identifying modulators of the NF-κB pathway.

NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health

The potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA are outlined to determine whether these phytochemicalicals can be used as functional foods.

NFκB: a promising target for natural products in cancer chemoprevention

The functions ofNFκB, its role in human cancer and the therapeutic potential and benefit of targeting NFκB by natural products in cancer chemoprevention are focused on.

Plant Natural Products as Potential Modulators of the Transcription Factor NF- B

This review surveys the plant natural products with significant NF-� B inhibitory activity focusing on their potential mechanism of action and their implications for cancer therapy.

Inhibition of TNFα-induced activation of nuclear factor κB by kava (Piper methysticum) derivatives

Molecular basis of the anti-inflammatory effects of terpenoids.

Molecular basis of the anti-inflammatory action of diterpenoids is presented with special emphasis on their ability to modulate critical cell signaling pathways involved in the inflammatory response of the body such as nuclear transcription factor- kappaB (NF-kappaB) activation.

Plant extracts of spices and coffee synergistically dampen nuclear factor-κB in U937 cells.

Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators.

...

References

SHOWING 1-10 OF 210 REFERENCES

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer.

NF-κB comprises a family of inducible transcription factors that serve as important regulators of the host immune and inflammatory response. In addition, NF-κB is also involved in protecting cells…

Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF‐κB

Inhibition of the Nuclear Factor κB (NF-κB) Pathway by Tetracyclic Kaurene Diterpenes in Macrophages

Results show that kaurenes impair the inflammatory signaling by inhibiting NIK, a member of the MAPK kinase superfamily that interacts with tumor necrosis factor receptor-associated factors, and mediate the activation of NF-κB by these receptors.

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

A novel mechanism of anti-inflammatory activity which is based on the direct inhibition and modification of the IKKβ subunit of IKK is demonstrated, which explains how cyclopentenone prostaglandins function and can be used to improve the utility of COX2 inhibitors.

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane) (*)

It is demonstrated that curcumin (diferuloylmethane), a known anti-inflammatory and anticarcinogenic agent, is a potent inhibitor of NF-κB activation.

The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex

The sesquiterpene lactone parthenolide could serve as a lead compound for the development of antiinflammatory remedies and is suitable as a molecular tool, allowing the dissection of TNF-α-derived signaling pathways leading to the activation of NF-κB, c-Jun N-terminal kinase, and p38.

Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-κB, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation1

Resveratrol’s anticarcinogenic, anti-inflammatory, and growth-modulatory effects may be partially ascribed to the inhibition of activation of NF-κB and AP-1 and the associated kinases.

Naturally occurring and synthetic inhibitors of NF-kappaB functions.

The designed compound, DHM2EQ, inhibited TNF-alpha-induced activation of NF-kappaB and showed a therapeutic effect in mouse rheumatoid arthritis model and was synthesized from the structure of an antibiotic, epoxyquinomicin C.

NF-κB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment

Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β*

Inhibition of NF-κB by SLs resulted in an enhanced cell killing of murine fibroblast cells by tumor necrosis factor-α and the analysis of the cellular redox state by fluorescence-activated cell sorter showed that the SLs had no direct or indirect anti-oxidant properties.
...