Natural products and colon cancer: current status and future prospects

@article{Rajamanickam2008NaturalPA,
  title={Natural products and colon cancer: current status and future prospects},
  author={Subapriya Rajamanickam and Rajesh Agarwal},
  journal={Drug Development Research},
  year={2008},
  volume={69}
}
Carcinogenesis is a multistage process consisting of initiation, promotion, and progression phases. Thus, the multistage sequence of events has many phases for prevention and intervention. Chemoprevention, a novel approach for controlling cancer, involves the use of specific natural products or synthetic chemical agents to reverse, suppress, or prevent premalignancy before the development of invasive cancer. Several natural products including grains, nuts, cereals, spices, fruits, vegetables… Expand
The Chemopreventive Properties and Therapeutic Modulation of Green Tea Polyphenols in Oral Squamous Cell Carcinoma
TLDR
The role of green tea in oral cancer chemoprevention is discussed with regard to the multiple molecular mechanisms proposed in various in vitro, in vivo, and clinical trials. Expand
Nutraceuticals as potential therapeutic agents for colon cancer: a review
TLDR
The medicinal importance of nutraceuticals and their ability to reduce the risk of colorectal carcinogenesis are discussed. Expand
Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
TLDR
The consolidation of the considerable body of data on the diverse targets of the lignans will aid continued research into their potential for use in combination with other cancer chemotherapies, utilizing flaxseed lignan-enriched natural products. Expand
Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention.
TLDR
A deeper understanding of how these anti-inflammatory agents inhibit CRC will provide insight into the development of potentially safer and more effective chemopreventive drugs. Expand
Phytochemicals and colorectal cancer prevention—myth or reality?
TLDR
Future chemopreventive work should focus on delivering phytochemical mixtures that target the multiple molecular events involved in colorectal carcinogenesis, as enforcing dietary interventions on large populations is not realistic. Expand
Natural Compounds as Adjuncts for Treating Colon Cancer through Apoptotic Pathway
Cancer is one of the deadliest diseases which is caused when abnormal cells divide uncontrollably and destroy body tissue. Colorectal cancer (CRC), also known as colon cancer, is one of the mostExpand
Chemopreventive and Anticancer Efficacy of Silibinin Against Colorectal Cancer
TLDR
Over the years, preclinical studies have shown that silibinin has strong preventive and therapeutic efficacy against various epithelial cancers, including CRC, and these studies advocate the efficacy evaluation of silibInin in clinical trials, both as a CRC preventive agent and as an “adjunct therapy” for uses in clinical cases where current treatment approaches fail to cause absolute suppression of CRC. Expand
Identifying Molecular Targets of Lifestyle Modifications in Colon Cancer Prevention
TLDR
The following is a comprehensive review identifying downstream target proteins of the above lifestyle risk factors, which are modulated during colon carcinogenesis and could be targeted for CRC prevention by novel agents including phytochemicals. Expand
Cellular and molecular targets of silibinin, a natural flavonoid, in colorectal cancer prevention and therapy
TLDR
In the preclinical model in the rat, silibinin administration was able to reduce by half the number of preneoplastic lesions present in the colon and for combination therapy with TRAIL/HDAC inhibitors. Expand
Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy
TLDR
The ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC, and use these natural agents as a safe intervention strategy during the clinical course of this deadly malignancy. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 106 REFERENCES
Botanicals in Cancer Chemoprevention
TLDR
Several lead compounds, such as brassinin (from cruciferous vegetables like Chinese cabbage), sulforaphane (from broccoli) and its analog sulforamate, withanolides (from tomatillos), and resveratrol (from grapes and peanuts) are in preclinical or clinical trials for cancer chemoprevention. Expand
Chemoprevention of Colon Cancer: Current Status and Future Prospects
TLDR
The perspective of the future prospects in this scientific area is provided and has been predicated primarily on the firm belief that the proper integration of advances in the biology of colon carcinogenesis, experimental therapeutics and clinical trial methodology will be critical for the success of this promising field. Expand
Innovative agents in cancer prevention.
TLDR
It may be possible not only to suppress tumours and to extend quality of life by administering appropriate diet-derived molecules, but also to refine the definition of a cancer chemopreventive diet, as more research effort is being targeted towards this area. Expand
Targeting signal transduction pathways by chemopreventive agents.
TLDR
Recent work regarding three well-accepted cellular/molecular mechanisms that may at least partially explain the effectiveness of selected food factors, including those indicated above, as chemopreventive anti-promotion agents are focused on. Expand
Current strategies for anticancer chemoprevention and chemoprotection.
TLDR
Overall, potential targets in preventive strategies to reduce the risk of cancer involve agonists of endocrine receptors, factors down-regulating inflammation, factors inducing programmed cell death (PCD)/apoptosis, enzymatic inhibitors and gene therapy. Expand
Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis.
TLDR
Examination of intestinal tissue from the treated animals showed that tumor prevention by CAPE and curcumin was associated with increased enterocyte apoptosis and proliferation, and these data place the plant phenolicsCAPE andCurcumin among a growing list of anti-inflammatory agents that suppress Apc-associated intestinal carcinogenesis. Expand
Aged garlic extract inhibits angiogenesis and proliferation of colorectal carcinoma cells.
TLDR
The results suggest that AGE could prevent tumor formation by inhibiting angiogenesis through the suppression of endothelial cell motility, proliferation, and tube formation and would be a good chemopreventive agent for colorectal cancer. Expand
Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention.
TLDR
It is demonstrated for the first time that the lipid fraction of wheat bran has strong colon tumor inhibitor properties, and the specific WB fractions such as WB fiber, WB lipids, or phytic acid differentially affect colon carcinogenesis in a well-established colon cancer model. Expand
Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells
TLDR
GSE may be an effective chemopreventive agent against colorectal cancer, and that growth inhibitory and apoptotic effects of GSE could be mediated via an up-regulation of Cip1/p21. Expand
Dietary modulation of colon cancer risk.
TLDR
Evidence exists that butyrate reduces the number and the size of aberrant crypt foci in the colon and there are uncertainties that remain to be resolved including the optimal exposure needed to bring about an effect, the appropriate timing of administration, and if nutrient-nutrient and nutrient-gene interactions determine the overall response. Expand
...
1
2
3
4
5
...