Natural products and Pharma 2011: strategic changes spur new opportunities.

  title={Natural products and Pharma 2011: strategic changes spur new opportunities.},
  author={Guy T Carter},
  journal={Natural product reports},
  volume={28 11},
Although natural products have been marginalized by major pharmaceutical companies over the last 20-30 years, the changing landscape of drug discovery now favors a greatly enhanced role for Nature's privileged structures. Screening for drug leads in phenotypic screens provides the best opportunity to realize the value of natural products. Advances in total synthesis, especially function-oriented syntheses and biosynthetic technologies offer new avenues for the medicinal chemical optimization of… CONTINUE READING
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