Natural products--the future scaffolds for novel antibiotics?

  title={Natural products--the future scaffolds for novel antibiotics?},
  author={Mark S Butler and Antony David Buss},
  journal={Biochemical pharmacology},
  volume={71 7},
Natural products have played a pivotal role in antibiotic drug discovery with most antibacterial drugs being derived from a natural product or natural product lead. However, the rapid onset of resistance to most antibacterial drugs diminishes their effectiveness considerably and necessitates a constant supply of new antibiotics for effective treatment of infections. The natural product templates of actinonin, pleuromutilin, ramoplanin and tiacumicin B, which are compounds undergoing clinical… CONTINUE READING