Natural products: a continuing source of novel drug leads.

  title={Natural products: a continuing source of novel drug leads.},
  author={Gordon M. Cragg and David J. Newman},
  journal={Biochimica et biophysica acta},
  volume={1830 6},
BACKGROUND Nature has been a source of medicinal products for millennia, with many useful drugs developed from plant sources. Following discovery of the penicillins, drug discovery from microbial sources occurred and diving techniques in the 1970s opened the seas. Combinatorial chemistry (late 1980s), shifted the focus of drug discovery efforts from Nature to the laboratory bench. SCOPE OF REVIEW This review traces natural products drug discovery, outlining important drugs from natural… CONTINUE READING
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