Natural production and functional effects of alternatively spliced interleukin-4 protein in asthma.

@article{Luzina2012NaturalPA,
  title={Natural production and functional effects of alternatively spliced interleukin-4 protein in asthma.},
  author={Irina G. Luzina and Virginia Lockatell and Sachin Lavania and Edward M. Pickering and Phillip H. Kang and Yulia N Bashkatova and Sergey M Andreev and Sergei P. Atamas},
  journal={Cytokine},
  year={2012},
  volume={58 1},
  pages={20-6}
}
We have previously described an alternatively spliced isoform of IL-4 mRNA that omits exon 2 and is termed IL-4δ2. However, the natural production of IL-4δ2 protein and its association with disease have not been previously assessed due to unavailability of an antibody that interacts with IL-4δ2 without cross-reactivity with full length IL-4. We used a unique monoclonal antibody (mAb) that reacts with IL-4δ2, but not with IL-4, and observed that IL-4δ2 is naturally produced by T cells from… CONTINUE READING

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