Natural product synthesis: changes over time.

  title={Natural product synthesis: changes over time.},
  author={Reinhard W Hoffmann},
  journal={Angewandte Chemie},
  volume={52 1},
For almost 200 years, the synthesis of natural products has been practiced. In this time span, not only the target structures have become increasingly more complex, the objectives of natural product synthesis have also changed. Likewise, the standards and criteria for the conduction of natural product synthesis have changed. It is these changes that form the subject of this Essay. 
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