Natural product-guided discovery of a fungal chitinase inhibitor.

  title={Natural product-guided discovery of a fungal chitinase inhibitor.},
  author={Christina L Rush and Alexander W Sch{\"u}ttelkopf and Ramon Hurtado-Guerrero and David E. Blair and Adel Mohammad Ibrahim and St{\'e}phanie Desvergnes and Ian M. Eggleston and Daan M F van Aalten},
  journal={Chemistry & biology},
  volume={17 12},
Natural products are often large, synthetically intractable molecules, yet frequently offer surprising inroads into previously unexplored chemical space for enzyme inhibitors. Argifin is a cyclic pentapeptide that was originally isolated as a fungal natural product. It competitively inhibits family 18 chitinases by mimicking the chitooligosaccharide substrate of these enzymes. Interestingly, argifin is a nanomolar inhibitor of the bacterial-type subfamily of fungal chitinases that possess an… CONTINUE READING
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