Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors.

@article{Brents2012NaturalPR,
  title={Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors.},
  author={Lisa K. Brents and Fabricio Medina-Bolivar and Kathryn A. Seely and Vipin Devi Prasad Nair and Stacie M. Bratton and Luis H. Nopo-Olazabal and Ronak Y. Patel and Haining Liu and Robert J. Doerksen and Paul L. Prather and Anna Radomińska-Pandya},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2012},
  volume={42 2},
  pages={139-56}
}
RATIONALE The therapeutic promise of trans-resveratrol (tRes) is limited by poor bioavailability following rapid metabolism. We hypothesise that trans-arachidin-1 (tA1) and trans-arachidin-3 (tA3), peanut hairy root-derived isoprenylated analogs of tRes, will exhibit slower metabolism/enhanced bioavailability and retain biological activity via cannabinoid receptor (CBR) binding relative to their non-prenylated parent compounds trans-piceatannol (tPice) and tRes, respectively. RESULTS The… CONTINUE READING