Natural potent androgens: lessons from human genetic models.

  title={Natural potent androgens: lessons from human genetic models.},
  author={Yuanshan Zhu and Matthew D. Katz and Julianne L Imperato-McGinley},
  journal={Bailliere's clinical endocrinology and metabolism},
  volume={12 1},
Male pseudohermaphroditism due to 17 beta-hydroxysteroid dehydrogenase-3 (17 beta-HSD-3) deficiency and 5 alpha-reductase-2 (5 alpha-RD-2) deficiency provides natural human genetic models to elucidate androgen actions. To date, five 17 beta-HSD isozymes have been cloned that catalyse the oxidoreduction of androstenedione and testosterone and dihydrotestosterone (DHT), oestrone and oestradiol. Mutations in the isozyme 17 beta-HSD-3 gene are responsible for male pseudohermaphroditism due to 17… CONTINUE READING


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