Natural potent androgens: lessons from human genetic models.

@article{Zhu1998NaturalPA,
  title={Natural potent androgens: lessons from human genetic models.},
  author={Yuanshan Zhu and Matthew D. Katz and Julianne L Imperato-McGinley},
  journal={Bailliere's clinical endocrinology and metabolism},
  year={1998},
  volume={12 1},
  pages={83-113}
}
Male pseudohermaphroditism due to 17 beta-hydroxysteroid dehydrogenase-3 (17 beta-HSD-3) deficiency and 5 alpha-reductase-2 (5 alpha-RD-2) deficiency provides natural human genetic models to elucidate androgen actions. To date, five 17 beta-HSD isozymes have been cloned that catalyse the oxidoreduction of androstenedione and testosterone and dihydrotestosterone (DHT), oestrone and oestradiol. Mutations in the isozyme 17 beta-HSD-3 gene are responsible for male pseudohermaphroditism due to 17… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

5-Alpha reductase deficiency: a 40-year retrospective review.

Current opinion in endocrinology, diabetes, and obesity • 2014

Androgen stimulates endothelial cell proliferation via an androgen receptor/VEGF/cyclin A-mediated mechanism.

American journal of physiology. Heart and circulatory physiology • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…