Natural post-translational modifications of chemokines.

  title={Natural post-translational modifications of chemokines.},
  author={Paul Proost and Sofie Struyf and Jo Van Damme},
  journal={Biochemical Society transactions},
  volume={34 Pt 6},
Chemokines, adhesion molecules, cytokines and proteases regulate the extravasation of leucocytes during acute and chronic inflammation and leucocyte homing. Chemokines are produced after transcriptional activation by inflammatory mediators such as cytokines or microbial Toll-like receptor ligands and their effect depends on the expression of chemokine receptors on specific cell types. More and more evidence points towards a role for post-translational modifications in the fine-tuning of… CONTINUE READING


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