Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal.

@article{Zhu2009NaturalPA,
  title={Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal.},
  author={Q. Zhu and Zong-Ping Zheng and Ka-Wing Cheng and Jia-jun Wu and Shuo Zhang and Y. Tang and K. Sze and J. Chen and F. Chen and Mingfu Wang},
  journal={Chemical research in toxicology},
  year={2009},
  volume={22 10},
  pages={
          1721-7
        }
}
Acrolein (ACR) and 4-hydroxy-trans-2-nonenal (HNE) are two cytotoxic lipid-derived alpha,beta-unsaturated aldehydes which have been implicated as causative agents in the development of carbonyl stress-associated pathologies. In this study, 21 natural polyphenols were screened to identify effective scavenging agents of ACR and/or HNE in simulated physiological conditions. It was found that flavan-3-ols, theaflavins, cyanomaclurin, and dihydrochalcones effectively trapped ACR and HNE by working… Expand
Mechanistic studies of inhibition on acrolein by myricetin.
Acrolein scavengers: reactivity, mechanism and impact on health.
In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple.
Epoxyalkenal-trapping ability of phenolic compounds.
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