Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors.

@article{Low2009NaturalPO,
  title={Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors.},
  author={Andrea Low and Nicole Prada and Michael B Topper and Florin Vaida and Delivette Castor and Hiroshi Mohri and Daria Hazuda and Mark A. Muesing and Martin Markowitz},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 10},
  pages={4275-82}
}
We evaluated the human immunodeficiency virus type 1 (HIV-1) integrase coding region of the pol gene for the presence of natural polymorphisms in patients during early infection (AHI) and with triple-class drug-resistant HIV-1 (MDR). We analyzed selected recombinant viruses containing patient-derived HIV-1 integrase for susceptibility to a panel of strand transfer integrase inhibitors (InSTI). A pretreatment sequence analysis of the integrase coding region was performed for 112 patients… CONTINUE READING

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