Natural polyclonality of spontaneous AKR leukemia and its consequences for so-called specific immunotherapy.

@article{Olsson1979NaturalPO,
  title={Natural polyclonality of spontaneous AKR leukemia and its consequences for so-called specific immunotherapy.},
  author={L E Olsson and Peter Ebbesen},
  journal={Journal of the National Cancer Institute},
  year={1979},
  volume={62 3},
  pages={623-7}
}
Young female AKR mice made leukemic by iv inoculation of 10(3) spontaneous AKR thymoma cells were treated with repeated injections of irradiated cells from the same tumor. Treatment began 1 day after injection of the viable cells. The cytotoxicity of sera and lymphoid cells from healthy mice immunized with lymphoma cells from either treated or nontreated mice with leukemia grafts revealed that the tumor cells could be subdivided into four distinct antigenic types. One type (clone A) accounted… CONTINUE READING

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Advances in Immunity and Cancer Therapy • 1985

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