Natural occurrence of myofiber cytoplasmic enlargement accompanied by decrease in myonuclear number.

@article{Wada2003NaturalOO,
  title={Natural occurrence of myofiber cytoplasmic enlargement accompanied by decrease in myonuclear number.},
  author={K I Wada and Shigeru Katsuta and Hideaki Soya},
  journal={The Japanese journal of physiology},
  year={2003},
  volume={53 2},
  pages={145-50}
}
It has been shown that changes in the nuclear number in myofibers are synchronized with myofiber size. Therefore, under some conditions, the myonuclear number is thought to be a determinant factor of myofiber size. However, we have clearly shown that denervation-induced fiber atrophy occurs without any decrease in myonuclear number, indicating that the myonuclear number is not always an important determinant factor of myofiber size. However, this was an event found under experimental conditions… CONTINUE READING