Natural noxious stimulation can induce long-term increase of spinal nociceptive responses

@article{Rygh1999NaturalNS,
  title={Natural noxious stimulation can induce long-term increase of spinal nociceptive responses},
  author={Lars J\orgen Rygh and Frode Svendsen and Kjell Hole and Arne Tj\olsen},
  journal={PAIN},
  year={1999},
  volume={82},
  pages={305-310}
}
It is conceivable that plasticity in pain control systems and chronic pain may be due to mechanisms similar to learning. Long-term potentiation (LTP) in the hippocampus is often studied as a model of learning and memory. It has recently been shown that long-term excitation may be induced in single wide dynamic range (WDR) neurones in the spinal dorsal horn of rats after tetanic stimulation to the sciatic nerve. The present study shows that similar long-term changes can also be induced by a… CONTINUE READING

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