Natural loss of Purkinje cells during development and increased loss with alcohol

@article{Cragg1985NaturalLO,
  title={Natural loss of Purkinje cells during development and increased loss with alcohol},
  author={B. G. Cragg and Stephen C. Phillips},
  journal={Brain Research},
  year={1985},
  volume={325},
  pages={151-160}
}
In untreated rats, degenerating Purkinje cells (P cells) were present from the 20th day of embryonic life (E20) to post-natal day 14 (PN14), but none was present on E17 or PN15. Ethanol increased the loss of P cells both before birth and up to PN6 or 8, but from PN10 no increased loss was seen. Most degenerating P cells were located below the P cell line. On PN3 ethanol killed some P cells in 12 h, and the first ultrastructural change was a dilatation of the nuclear double membrane after 8 h… CONTINUE READING

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