Natural kirromycin resistance of elongation factor Tu from the kirrothricin producer Streptomyces cinnamoneus.

@article{Cappellano1997NaturalKR,
  title={Natural kirromycin resistance of elongation factor Tu from the kirrothricin producer Streptomyces cinnamoneus.},
  author={Carmela M. Cappellano and Federica Monti and M. Sosio and Stefano Donadio and Edoardo Sarubbi},
  journal={Microbiology},
  year={1997},
  volume={143 ( Pt 2)},
  pages={617-24}
}
The antibiotic kirromycin (Kr) inhibits bacterial protein synthesis by binding to elongation factor Tu (EF-Tu). Streptomyces cinnamoneus and Nocardia lactamdurans, producers of antibiotics of the Kr class, are known to possess an EF-Tu resistant to Kr. Both micro-organisms appear to possess a single tuf gene and we have characterized the one from S. cinnamoneus, which belongs to the tuf1 family. To assess the molecular determinants of Kr resistance, the S. cinnamoneus tuf gene was expressed in… CONTINUE READING
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Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 32 references

Mechanism of natural resistance to kirromycin-type antibiotics in actinomycetes

  • C. Glo ckner, H. Wolf
  • FEMS Microbiol Lett
  • 1984
Highly Influential
4 Excerpts

Metabolic products of microorganisms. Kirrothricin, a new member of the kirromycin-group

  • I. Thein-Schrammer, H. Zahner, Hopper, H.-U, I. Hummel, A. Zeeck
  • J Antibiot
  • 1982
Highly Influential
4 Excerpts

Cloning and sequencing of the tuf genes of Streptomyces coelicolor A3(2)

  • G. P. van Wezel, L. P. Woudt, R. Vervenne, M.L.A. Verdurmen, E. Vijgenboom, L. Bosch
  • Biochim Biophys Acta
  • 1994
Highly Influential
4 Excerpts

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