Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells.

@article{Kawano1998NaturalKN,
  title={Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells.},
  author={Tetsu Kawano and Junqing Cui and Yasuhiko Koezuka and Isao Toura and Yoshikatsu Kaneko and Hiromu Sato and Eisei Kondo and Michishige Harada and Haruhiko Koseki and Toshinori Nakayama and Yoshimasa Tanaka and Masaru Taniguchi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 10},
  pages={5690-3}
}
We have recently identified alpha-galactosylceramide (alpha-GalCer) as a specific ligand for an invariant Valpha14/Vbeta8.2 T cell receptor exclusively expressed on the majority of Valpha14 NKT cells, a novel subset of lymphocytes. Here, we report that alpha-GalCer selectively activates Valpha14 NKT cells resulting in prevention of tumor metastasis. The effector mechanisms of the ligand-activated Valpha14 NKT cells seem to be mediated by natural killer (NK)-like nonspecific cytotoxicity. Indeed… CONTINUE READING