Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties.

@article{Boysen2008NaturalKC,
  title={Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties.},
  author={Preben Boysen and Gjermund Gunnes and Daniela Pende and Mette Valheim and Anne Kristine Storset},
  journal={Developmental and comparative immunology},
  year={2008},
  volume={32 7},
  pages={773-83}
}
Natural killer (NK) cells were recently shown to play an important immunomodulatory role in lymph nodes. We here report the presence, phenotype and function of NK cells resident in lymph nodes of several anatomical sites of healthy calves. NKp46+/CD3-lymphocytes, recently demonstrated to precisely identify NK cells in all tested species, were present in the paracortex and the medulla of bovine lymph nodes. Most lymph node-derived NK cells expressed CD16 and perforin, and a lytic capacity was… CONTINUE READING

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