Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice

@article{Scharton1993NaturalKC,
  title={Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice},
  author={T M Scharton and Phillip Scott},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={567 - 577}
}
Infection of mice with the protozoan Leishmania major provides an excellent model to define the factors involved in T helper (Th) subset development, since Th1 cells confer protection in resistant strains of mice, whereas Th2 cells are associated with the fatal outcome of susceptible mice. We previously found that interferon gamma (IFN-gamma) was required for Th1 cell development after infection of mice with L. major. In this report, we evaluate the contribution of natural killer (NK) cells to… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 196 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 66 references

11 .4 induces a Th 2 response in Leishmania major - infected mice

  • P. Scott
  • 1992

Induction of Thl and Th 2 responses : a key role for the ' natural ' immune response ?

  • B. Perussia
  • Immunol . Today .
  • 1992

Induction of Thl and Th2 responses: a key role for the 'natural' immune response? Immunol

  • S. Komagnani
  • 1992

Similar Papers

Loading similar papers…