Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses.

@article{Mocikat2003NaturalKC,
  title={Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses.},
  author={Ralph Mocikat and Heidi Braum{\"u}ller and Alain Gumy and Oliver Egeter and Heike Ziegler and Uwe Reusch and Anja Bubeck and Jacques Louis and Reinhard Mailhammer and Gert Riethmueller and Ulrich Koszinowski and Martin Roecken},
  journal={Immunity},
  year={2003},
  volume={19 4},
  pages={561-9}
}
Conserved molecular patterns derived from pathogenic microorganisms prime antigen-presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus-infected or tumor cells that express low levels of major histocompatibility complex (MHC) class I activate natural killer (NK) cells for direct killing. It is unknown whether NK cell recognition of MHC class I(low) targets can also induce adaptive T cell responses. Here, we show that MHC class I(low) targets initiate a cascade… CONTINUE READING