Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization.

@article{Romo2011NaturalKC,
  title={Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization.},
  author={Neus Romo and Giuliana Magri and Aura Muntasell and Gemma Heredia and Diogo Ba{\'i}a and Ana Angulo and M{\'o}nica Gum{\'a} and Miguel L{\'o}pez-Botet},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={90 4},
  pages={717-26}
}
MΦ comprise a heterogeneous population of cells, which contribute to host defense and maintenance of immune homeostasis. MΦ may be infected by human cytomegalovirus (HCMV), which has evolved different strategies to subvert the immune response. In the present study, we comparatively analyzed the natural killer (NK) cell response against HCMV (TB40E)-infected proinflammatory (M1) and antinflammatory (M2) MΦ, derived from autologous monocytes, cultured in the presence of GM-CSF and M-CSF… CONTINUE READING

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