Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-α, interferon-γ and interleukin-12.

@article{MajewskaSzczepanik2013NaturalKC,
  title={Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-α, interferon-γ and interleukin-12.},
  author={Monika Majewska-Szczepanik and Silke Paust and Ulrich H von Andrian and Philip W. Askenase and Marian Szczepanik},
  journal={Immunology},
  year={2013},
  volume={140 1},
  pages={98-110}
}
Natural killer (NK) cell-mediated contact sensitivity was recently described in mice. Here, we confirm NK cell-mediated contact sensitivity (CS) in SCID and RAG1(-/-) mice but not in SCIDbeige mice, which have non-functional NK cells that lack NK cell granules. NK cell-mediated CS was transferred by liver mononuclear cells and the DX5(+) fraction of liver cells, confirming that NK cells mediate CS in the absence of T and B cells. Participation of NKT cells and B-1 cells was ruled out using Jα18… CONTINUE READING

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