Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNalpha gene to mice.

@article{Takehara2007NaturalKC,
  title={Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNalpha gene to mice.},
  author={Tetsuo Takehara and Akio Uemura and Tomohide Tatsumi and Takahiro Suzuki and Ritsuko Kimura and Ai Shiotani and Kazuyoshi Ohkawa and Tatsuya Kanto and Naoki Hiramatsu and Norio Hayashi},
  journal={International journal of cancer},
  year={2007},
  volume={120 6},
  pages={1252-60}
}
Interferon (IFN) alpha is a pleiotropic cytokine acting as an antiviral substance, cell growth inhibitor and immunomodulator. To evaluate the therapeutic efficacy and mechanisms of IFNalpha on hepatic metastasis of tumor cells, we hydrodynamically injected naked plasmid DNA encoding IFNalpha1 (pCMV-IFNa1) into Balb/cA mice having 2 days hepatic metastasis of CT-26 cells. Single injection of pCMV-IFNa1 efficiently enhanced the natural killer (NK) activity of hepatic mononuclear cells, induced… CONTINUE READING
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