Natural killer cell dysfunction during acute infection with foot-and-mouth disease virus.

@article{Toka2009NaturalKC,
  title={Natural killer cell dysfunction during acute infection with foot-and-mouth disease virus.},
  author={Felix N Toka and Charles Nfon and Harry Dawson and William T. Golde},
  journal={Clinical and vaccine immunology : CVI},
  year={2009},
  volume={16 12},
  pages={1738-49}
}
Natural killer (NK) cells provide one of the initial barriers of cellular host defense against pathogens, in particular intracellular pathogens. The role of these cells in foot-and-mouth disease virus (FMDV) infection is unknown. Previously, we characterized the phenotype and function of NK cells from swine (F. N. Toka et al., J. Interferon Cytokine Res. 29:179-192, 2009). In the present study, we report the analysis of NK cells isolated from animals infected with FMDV and tested ex vivo and… CONTINUE READING