Natural killer cell development is blocked in the context of aberrant T lymphocyte ontogeny.

@article{Wang1996NaturalKC,
  title={Natural killer cell development is blocked in the context of aberrant T lymphocyte ontogeny.},
  author={Bin Wang and Georg A. Hollander and Aliki Nichogiannopoulou and Stephen J. Simpson and Jordan S Orange and Jos{\'e} Carlos Guti{\'e}rrez-Ramos and Steven J. Burakoff and Christine A. Biron A. Biron and Cox Terhorst},
  journal={International immunology},
  year={1996},
  volume={8 6},
  pages={939-49}
}
Over-expression of human or mouse CD3-epsilon transgenes profoundly disturbs T lymphocyte and natural killer (NK) cell development. One of these transgenic strains, termed tgepsilon26, displays a very early block in T lymphocyte and NK cell development. We showed previously that the absence of early thymocyte progenitors results in an abnormal thymic microenvironment. Due to this thymic defect, T cell development could not be restored by bone marrow (BM) transplantation in adult tgepsilon26… CONTINUE READING

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