Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes.

@article{Ashiru2010NaturalKC,
  title={Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes.},
  author={Omodele Ashiru and Philippe Boutet and Lola Fern{\'a}ndez-Messina and Sonia Ag{\"u}era-Gonz{\'a}lez and Jeremy N. Skepper and Mar Val{\'e}s-G{\'o}mez and Hugh Thomson Reyburn},
  journal={Cancer research},
  year={2010},
  volume={70 2},
  pages={481-9}
}
The MHC class I-related chain (MIC) A and MICB ligands for the activating receptor NKG2D can be shed from tumor cells, and the presence of these soluble molecules in sera is related with compromised immune response and progression of disease. Recently, thiol disulphide isomerases and members of the ADAM (a disintegrin and metalloproteinase) gene family were identified as key enzymes in mediating MICA/B shedding from cells. Here, we report shedding of the most frequently expressed MICA allele in… CONTINUE READING
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