Natural killer cell cytotoxicity: how do they pull the trigger?

  title={Natural killer cell cytotoxicity: how do they pull the trigger?},
  author={Nicola J Topham and Eric W Hewitt},
  volume={128 1},
Natural killer (NK) cells target and kill aberrant cells, such as virally infected and tumorigenic cells. Killing is mediated by cytotoxic molecules which are stored within secretory lysosomes, a specialized exocytic organelle found in NK cells. Target cell recognition induces the formation of a lytic immunological synapse between the NK cell and its target. The polarized exocytosis of secretory lysosomes is then activated and these organelles release their cytotoxic contents at the lytic… CONTINUE READING
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