Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals

Abstract

Natural killer (NK) cells have originally been identified by their spontaneous cytolytic potential against tumor cells, which, however, might result from pre-activation due to prior pathogen exposure. Resting NK cells, on the contrary, require activation by bystander antigen-presenting cells to reach their full functional competence. In this review, we will… (More)
DOI: 10.1007/s00018-011-0801-8

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