Natural killer T cells promote collagen-induced arthritis in DBA/1 mice.

  title={Natural killer T cells promote collagen-induced arthritis in DBA/1 mice.},
  author={Sundo Jung and Hyun-Suk Shin and Changwan Hong and Hyunji Lee and Yoon-Kyung Park and Jung H. Shin and Seokmann Hong and Gap Ryol Lee and Se-Ho Park},
  journal={Biochemical and biophysical research communications},
  volume={390 3},
The role of NKT cells in the pathogenesis of collagen-induced arthritis (CIA) remains unclear since most studies have used C57BL/6 (B6) mice, which are less susceptible to CIA than mice with a DBA/1 background. To clarify the immunological functions of NKT cells in CIA, it is necessary to analyze in detail the effects of NKT cell deficiency on CIA development in DBA/1 mice. The incidence and severity of CIA were significantly exacerbated in DBA/1CD1d(+/-) mice as compared to DBA/1CD1d(-/-) mice… CONTINUE READING

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