Natural killer T cells: natural or unnatural regulators of autoimmunity?

  title={Natural killer T cells: natural or unnatural regulators of autoimmunity?},
  author={Kirsten J. L. Hammond and Mitchell Kronenberg},
  journal={Current opinion in immunology},
  volume={15 6},
Natural killer T (NKT) cells are a unique lymphocyte subtype implicated in the regulation of autoimmunity, particularly diabetes and experimental allergic encephalomyelitis in animal models. In some reports, NKT-cell regulation was revealed only following vigorous activation by a synthetic glycolipid, a process that might not occur naturally. Patients with diverse autoimmune diseases have reduced NKT-cell counts and, in diabetes and multiple sclerosis, effective NKT-cell regulation correlates… CONTINUE READING


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