Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury.

  title={Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury.},
  author={Ashish K Sharma and Damien J LaPar and Yun-ge Zhao and Li Li and Christine L. Lau and Irving L. Kron and Yoichiro Iwakura and Mark Douglas Okusa and Victor E Laubach},
  journal={American journal of respiratory and critical care medicine},
  volume={183 11},
RATIONALE We recently implicated a role for CD4(+) T cells and demonstrated elevated IL-17A expression in lung ischemia-reperfusion (IR) injury. However, identification of the specific subset of CD4(+) T cells and their mechanistic role in IR injury remains unknown. OBJECTIVES We tested the hypothesis that invariant natural killer T (iNKT) cells mediate lung IR injury via IL-17A signaling. METHODS Mice underwent lung IR via left hilar ligation. Pulmonary function was measured using an… CONTINUE READING


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