Natural inhibitors of toxic phospholipases A(2).

  title={Natural inhibitors of toxic phospholipases A(2).},
  author={Grazyna Faure},
  volume={82 9-10},
Endogenous proteins isolated from the serum of snakes have been found to be natural inhibitors displaying anti-hemorrhagic, anti-neurotoxic or anti-myotoxic activity. Some of these proteins inhibit phospholipase A(2) (PLA(2)) activity. We review in brief here the properties, structure and classification of these PLA(2) inhibitors (PLIs), focusing in particular on the mechanism of neutralization of the toxic PLA(2)s by anti-neurotoxic PLIs. We also discuss: 1) the protection provided by these… CONTINUE READING