Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

@article{Border1992NaturalIO,
  title={Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease},
  author={Wayne A. Border and N. Noble and Tatsuo Yamamoto and John R. Harper and Yu Yamaguchi and Michael D. Pierschbacher and Erkki Ruoslahti},
  journal={Nature},
  year={1992},
  volume={360},
  pages={361-364}
}
THE central pathological feature of human kidney disease that leads to kidney failure is the accumulation of extracellular matrix in glomeruli. Overexpression of transforming growth factor-β (TGF-β) underlies the accumulation of pathological matrix in experimental glomerulonephritis1. Administration of an antibody raised against TGF-β to glomerulonephritic rats suppresses glomerular matrix production and prevents matrix accumulation in the injured glomeruli2. One of the matrix components… CONTINUE READING
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