Natural infection with herpes simplex virus type 1 (HSV-1) induces humoral and T cell responses to the HSV-1 glycoprotein H:L complex.

@article{Westra2000NaturalIW,
  title={Natural infection with herpes simplex virus type 1 (HSV-1) induces humoral and T cell responses to the HSV-1 glycoprotein H:L complex.},
  author={Daniel Westra and Georges M G M Verjans and Albert D M E Osterhaus and Adriaan van Kooij and Gjalt W. Welling and Albert Jan Scheffer and T. Hauw The and Sytske Welling-Wester},
  journal={The Journal of general virology},
  year={2000},
  volume={81 Pt 8},
  pages={2011-5}
}
The glycoproteins of herpes simplex virus type 1 (HSV-1) are important targets for the immune system in the control of HSV-1 infections. The humoral and T cell responses to the glycoprotein (g)H(t(His)):gL complex of HSV-1 were studied in seven HSV-1-seropositive and three HSV-1-seronegative healthy adults. In addition, responses to HSV-1 gD(t) were determined. As antigens, purified soluble recombinant forms of the gH(t(His)):gL complex produced by insect cells and of gD(t) produced by yeast… CONTINUE READING

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