Natural history of young-adult amyotrophic lateral sclerosis

  title={Natural history of young-adult amyotrophic lateral sclerosis},
  author={Mario Sabatelli and Francesca Madia and Amelia Conte and Marco Luigetti and Marcella Zollino and Irene Mancuso and Mauro Lo Monaco and Gian Lippi and Pietro Attilio Tonali},
  pages={876 - 881}
Background: Amyotrophic lateral sclerosis (ALS) affects people of all ages, but whether the wide range of age at onset is due to distinct diseases or merely reflects phenotypic variability of the same disorder is still unknown. The purpose of this study is to describe clinical and prognostic features of young-adult ALS, with onset before age 40 years, and to compare them with features of the common adult-onset type. Methods: We analyzed clinical features and long-term follow-up of 57 young… 

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