Natural history of soy allergy and/or intolerance in children, and clinical use of soy‐protein formulas

  title={Natural history of soy allergy and/or intolerance in children, and clinical use of soy‐protein formulas},
  author={Arnaldo Cantani and Piergiorgio Lucenti},
  journal={Pediatric Allergy and Immunology},
Atopic diseases of infants and children are common, debilitating, chronic and sometimes even life‐threatening. Several well‐conducted studies in high risk babies have demonstrated a significant reduction in the prevalence and severity of atopic diseases with dietary and environmental manipulations. The currently available cow's milk (CM) substitutes for infants are soy protein (SP) formulas (SPFs), hydrolyzed formulas (HF), and home‐made meat‐based formulas. Soybeans have been cultivated in… 

Nutrition of allergic babies and children.

  • A. Cantani
  • Medicine
    European review for medical and pharmacological sciences
  • 1999
It is demonstrated that SPF allergy incidence in oral food challenge (OFC)/doubleblind food challenge-based epidemiological studies attains 3-4%, and CM-based protein hydrolysates have provoked 200 severe and less severe reactions.

Safety of soya-based infant formulas in children

Modern SIF are evidence-based safety options to feed children requiring them and the patterns of growth, bone health and metabolic, reproductive, endocrine, immune and neurological functions are similar to those observed in children fed CMF or HM.

Efficacy and Safety of Soy Protein Based Formula in Atopic Dermatitis

It is suggested that SPF could be useful in decreasing the severity of AD without affecting infant growth status and could provide an adequate and safe alternative to hCMF in treating infants with AD and CMA during the first 12 to 24 months of their life.

Soy and other protein sources

  • M. A. Muraro
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2001
In clinical practice, alternative protein sources from vegetable proteins such as soy, animal proteins, milk from different mammalian species or amino acid mixtures are employed and the safe use of these substitutes in infants who are allergic to cow’s milk should comply with the criteria used for hypoallergenic formulas.

Feeding high-risk infants with family history of allergy.

  • A. Cantani
  • Medicine
    European review for medical and pharmacological sciences
  • 1999
The ideal CM substitute should be hypoallergenic; have an adequate nutritional value according to the infant's age; be easily available and inexpensive; and be palatable in order to obtain a good compliance.

Dietary products used in infants for treatment and prevention of food allergy

I was disappointed that no word about this subject appeared in the conclusions of the statement, but believe that the conclusions should have been that soy based formulas are as allergenic as cow's milk protein.

Soy protein allergy: incidence and relative severity.

  • C. Cordle
  • Biology, Medicine
    The Journal of nutrition
  • 2004
Biochemical and immunochemical analyses indicate no striking differences between soy and other food proteins that would explain these unexpected differences in allergenic reactivity, and these data show substantially diminished immunological reactivity for soy proteins.

Fifth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease

Clinical data relevant to controversial aspects of feeding infants soy- based formulas, including nutritional adequacy, reproduc- tive development, neurobehavioral development, immune function, and thyroid disease are presented.

Dietary aspects of food allergy prevention in infants and children.

  • R. Zeiger
  • Medicine
    Journal of pediatric gastroenterology and nutrition
  • 2000
Identifying and developing effective strategies to prevent food and other allergic diseases represents a high priority for medicine at this time because of the unbridled increase in the prevalence and morbidity attributed to them.



Allergenicity and nutritional adequacy of soy protein formulas.

Effect of feeding whey hydrolysate, soy and conventional cow milk formulas on incidence of atopic disease in high risk infants.

It is concluded that exclusive breast feeding for more than 4 months is partially protective against the development of atopic disease among high risk infants.

Cumulative incidence of atopic disorders in high risk infants fed whey hydrolysate, soy, and conventional cow milk formulas.

It is shown that among infants at high risk of developing atopic disease because of positive family history, exclusive breast feeding or whey hydrolysate formula is associated with a lower incidence and thus a delay in the occurrence of allergic disorders compared with groups fed conventional cow milk or soy formulas.

Soy allergy in atopic children.

Comparison of Breast, Cow, and Soy Feedings in the Prevention of Onset of Allergic Disease

The hypothesis that breast feeding and delay of exposure to known allergens may reduce the frequency of clinical allergic disease in the offspring of allergic families is supported.

Recommendations for Soy Infant Formula: A Review of the Literature and a Survey of Pediatric Allergists

The availability of soybean formula provides parents of infants with cow's milk allergy a nutritional food that can be used in the preparation of many kinds of food dishes and desserts to provide variety for children on restrictive diets.

Soy hypersensitivity in children with food allergy.

To evaluate humoral (IgE antibodies) and clinical (positive challenge test) soy hypersensitivity prevalence, 317 children who visited the Division of Allergy and Clinical Immunology of the Pediatric Department of the University of Roma "La Sapienza" because of histories and symptoms suggestive of food allergy were studied.

Soy sensitivity: personal observation on 71 children with food intolerance.

Soy sensitivity is rather rare in patients with food intolerance and is not correlated with cow's milk intolerance while is significantly correlated with seeds allergy; there is no difference between atopic and non atopic subjects and between patients previously fed soy and never fed soy.

Influence of dietary manipulation on incidence of atopic disease in infants at risk.

Differences between the compliant group and the two groups with unrestricted diets were significant, indicating that this prescribed diet may protect against or delay onset of food allergies during the first year of life.