Natural history of muscle cramps in amyotrophic lateral sclerosis.

  title={Natural history of muscle cramps in amyotrophic lateral sclerosis.},
  author={James B. Caress and Stephanie L. Ciarlone and Elizabeth Ann Sullivan and Leah Passmore Griffin and Michael S. Cartwright},
  journal={Muscle & nerve},
  volume={53 4},
INTRODUCTION Muscle cramping is a common symptom in amyotrophic lateral sclerosis (ALS) that lacks efficacious treatment. The natural history of this symptom is unknown, which hampers efforts to design optimal clinical trials. METHODS We surveyed early stage ALS patients about their experience with cramps each month by phone for up to 21 months. RESULTS Cramps developed in 95% of patients over the course of their disease. The number of cramps experienced by an individual varied widely from… CONTINUE READING
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