Natural history of multiple sclerosis in a population-based cohort.

  title={Natural history of multiple sclerosis in a population-based cohort.},
  author={Marc Debouverie and Sophie Pittion-Vouyovitch and Susan Louis and Francis Guillemin},
  journal={European journal of neurology},
  volume={15 9},
BACKGROUND AND PURPOSE We sought to identify predictive clinical factors of disability during initial course in multiple sclerosis (MS) patients. METHODS A total of 2871 MS patients from the LORSEP (Lorraine Multiple Sclerosis) population-based cohort were analyzed. The relationships between baseline demographic, clinical predictors and time to assignment of Expanded Disability Status Scale (EDSS) scores of 3, 4 and 6 were assessed using a Cox regression model. RESULTS Multivariate analysis… CONTINUE READING

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