Natural history of multiple sclerosis
@article{Weinshenker2005NaturalHO, title={Natural history of multiple sclerosis}, author={Brian G. Weinshenker}, journal={Annals of Neurology}, year={2005}, volume={36} }
Multiple sclerosis (MS) is the most common idiopathic inflammatory disease of the central nervous system. The distinction between MS and other benign or fulminant inflammatory demyelinating disorders is based on quantitative, rather than qualitative, differences in chronicity and severity. Primary progressive MS may differ from relapsing‐remitting MS in MRI lesion frequency, immunogenetic profile, responsiveness to immunosuppressive treatment, and histology. In 60% of patients, MS begins as a…
191 Citations
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Patients with RRMS do not inevitably develop a progressive disease course, and onset of progression is more dependent on age than the presence or duration of a pre-progression symptomatic disease course.
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- Medicine, PsychologyPostepy higieny i medycyny doswiadczalnej
- 2017
Despite huge progress regarding MS as well as the availability of different diagnostics methods this disease is still a diagnostic challenge, due to fact that MS has diverse clinical course and there is a lack of single test, which would be of appropriate diagnostic sensitivity and specificity for quick and accurate diagnosis.
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- Medicine, Psychology
- 2014
The long-term prognosis was determined in a 50-year follow-up in the geographically and temporally defined “Gothenburg Incidence Cohort” and whether first generation immunomodulating drugs in the relapsing remitting phase delay the time to secondary progression was investigated.
Evidence for an Early Treatment of Multiple Sclerosis
- Medicine, Biology
- 2004
The demonstration of early irreversible axonal damage is a strong argument in favor of early treatment, an option that is beginning to be favored by many neurologists, and is probably explained by the complex pathogenesis of MS.
Predicting a window of therapeutic opportunity in multiple sclerosis.
- Biology, PsychologyBrain : a journal of neurology
- 2010
A contemporary analysis is that relapses represent multifocal inflammatory lesions, whereas the later, progressive phase is mainly driven by neurodegeneration, and the immunopathology may persist, albeit in an altered form, throughout the progressive phase.
The outcome spectrum of multiple sclerosis: disability, mortality, and a cluster of predictors from onset
- Medicine, PsychologyJournal of Neurology
- 2015
An incidence cohort of Gothenburg residents with MS onset in 1950–1964 provided hard outcome data in untreated patients over several decades, and predicted the disease course during five decades indirectly, by predicting time to secondary progression.
Clinical characteristics and long term prognosis in early onset multiple sclerosis
- Medicine, PsychologyJournal of Neurology
- 2006
It is confirmed that several specific clinical characteristics can be identified in EOMS patients, such as a mainly relapsing–remitting disease onset and frequent presentation with brainstem– cerebellar dysfunction, but after a long period of follow–up the overall disease course and prognosis do not seem to differ from that in adult onset MS.
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